Rule 34 mirrors edge
Such thinning could be measured in terms of reduction in either NRR area or NRR thickness.
In glaucoma, the functional damage is established most commonly by the occurrence of visual field (VF) loss whereas the structural damage is often characterized by neuroretinal rim (NRR) thinning of the optic nerve head (ONH), and loss of retinal nerve fibers, which are the axons of retinal ganglion cells (RGC). There are multiple sources of subjectivity and analytical challenges that are often encountered by the clinicians in the process of early diagnosis and clinical management of degenerative eye diseases. In 2020, an estimated 80 million individuals worldwide had glaucoma and this number is expected to increase to over 111 million by 2040 2. Glaucoma, for instance, is the second-leading cause of blindness worldwide 1. Indeed, early detection and management hold the key to slowing the progressive loss of vision and preventing blindness due to many chronic and age-related degenerative eye diseases. Progressive optic neuropathies such as glaucoma can cause irreversible blindness, especially when left untreated or diagnosed late. Our dataset also addresses the disparity of representation of this particular population in normative OCT databases. Upon stratification by age, we identified a healthy NRR phenotype cluster in the age group 40–49 years with predictive potential for glaucoma. We demonstrated CIFU by unsupervised circular functional clustering of the OCT NRR data, followed by meta-clustering to characterize the clusters using clinical covariates, and presented a circular visualization of the results. We introduced CIFU, a new computational pipeline for CIrcular FUnctional data modeling and analysis. We generated a dataset of Optical Coherence Tomography (OCT) based high-resolution circular measurements on NRR phenotypes, along with other clinical covariates, of 3973 healthy eyes as part of an established clinical cohort of Asian Indian participants. Baseline structural heterogeneity in the eyes can play a key role in the progression of optic neuropathies, and present challenges to clinical decision-making.
In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) thinning of the optic nerve head, and other clinical parameters. Multiple sources of subjectivity and analytical challenges are often encountered by clinicians in the process of early diagnosis and clinical management of these diseases. "I hope you agree that no one is above the law and your service needs to maintain public confidence that COVID rules apply equally to all people."Īsked whether there would be a Christmas party at Number 10 this year, the prime minister's official spokesman on Friday said there would "continue to be festive events" in the run-up to 25 December.īut the spokesman added any staff party would be a "private event" that would not be publicly announced.Progressive optic neuropathies such as glaucoma are major causes of blindness globally. "I believe your officers should investigate the matter further to establish the facts and to see if any laws might have been broken. "If these events did take place, it implies that there is one rule for the government and another for everyone else. "I was surprised to hear you say that the Metropolitan Police were not currently investigating the alleged party," he wrote in a letter. Subscribe to the All Out Politics podcast on Apple Podcasts, Google Podcasts, Spotify, Spreakerįollowing Dame Cressida's radio comments, Labour MP and former shadow minister Barry Gardiner wrote to the commissioner.